Zolmitriptan 2.5mg

Antimigraine; Serotonin 5-HT1B/1D Receptor Agonist

CSA NA – FDA Approved – REMS (N) – Can Ship

Zolmitriptan, Zomig is a selective agonist for serotonin 5-HT1B and 5-HT1D receptors.  These are located on intracranial blood vessels and sensory nerves of the trigeminal system and activating these receptors causes vasoconstriction and reduces neurogenic inflammation associated with antidromic neuronal transmission.  These actions are thought to be the cause of migraine relief.

Zolmitriptan, Zomig is officially indicated to treat acute migraines with or without aura.  It is also sometimes prescribed off-label to treat cluster headaches and for short term prevention of menstrual migraines.

Before starting Zolmitriptan, Zomig make sure your physician is aware of any allergies or medications you currently take (MAO inhibitors/ergotamine derivatives), if you have any cardiovascular disease, cerebrovascular disease, liver disease, a history of hemiplegic migraine, ophthalmoplegic migraine, are pregnant, or breastfeeding.  This medication has risk of causing serotonin syndrome especially if combined with other serotonergic drugs.  Before triptans are used a full cardiac workup including ECG may be considered.

1.25-10 mg per dose, can repeat dose in 2 hours if only partial relief or if symptoms return to a maximum of 10mg/24 hours. 

How to Take Zolmitriptan, Zomig: Follow instructions provided by physician/pharmacy label, with or without food, use at first sign of migraine symptoms, store at room temperature.   Dissolving tablets should be dissolved on tongue then swallowed with saliva.   It is important to note orally disintegrating tablets are not sublingual and their only benefit is that water is not needed, and it is easier for people with difficulty swallowing.  There is no difference in effect, or time before onset of action.

You Need to Avoid: Do not use triptans more than 10 times per month to avoid medication overuse headache.  

Unpleasant taste, muscle weakness, nausea, dry mouth, dizziness, drowsiness, fatigue, tingling sensation, chest pain, neck/throat/jaw pain

Note this is not a complete list of side effects, only common ones

1. What is a medication overuse headache?
   Using medication to treat headaches regularly over a long period of time can start resulting in causing a rebound headache.  Regular pain reliever use in people without a headache disorder does not result in this phenomenon.  Medication overuse headaches usually stop after pain medication is discontinued for a while which can be very difficult in the short term, but once completed result in long term relief.  Medication overuse headaches may differ depending on the original type of headache treated and the medication used, but they tend to occur every day, or nearly every day often waking one in the early morning and improve with use of pain medication but come back as soon as it wears off.  It is important to not overuse your pain medication and follow your physician’s instructions even if it means you have to tolerate headaches symptoms a few times a month to prevent this from occurring.
2. What is serotonin syndrome?
   Serotonin syndrome is a rare, but potentially life-threatening condition of serotonin toxicity from too much of it in your system generally from the use of certain medications and supplements.  Usually multiple agents are at play or high doses are involved.  The signs and symptoms include agitation, hallucinations, delirium, coma, tachycardia (rapid heart rate), diaphoresis (excessive sweating), tremor, muscle rigidity, nausea, vomiting, diarrhea, and/or seizures.  If serotonin syndrome is suspected, discontinue any serotonergic medications, and seek immediate medical attention.