Tranexamic Acid 500mg

Tranexamic Acid, Cyklokapron (US/CDN)/Lysteda (US)
Description: Antifibrinolytic Agent; Antihemophilic Agent; Hemostatic Agent; Lysine Analog

CSA NA – FDA Approved – REMS (N) – Can Ship

Tranexamic Acid, Cyklokapron/Lysteda forms a reversible complex that displaces plasminogen from fibrin resulting in inhibition of fibrinolysis.  It also inhibits plasmin proteolytic activity.

Menstrual bleeding, heavy (oral); Tooth extraction in patients with hemostatic defects (injection, oral)

Before starting Tranexamic Acid, Cyklokapron/Lysteda make sure your physician is aware of any allergies or medications you currently take, if you have disseminated intravascular coagulation, renal impairment, subarachnoid hemorrhage, vascular disease, are pregnant, or breastfeeding. Tranexamic Acid, Cyklokapron/Lysteda use has been associated with rare but serious adverse events such as dizziness, hypersensitivity reactions, ocular effects, seizure, and thrombotic events.

Menstrual Bleeding: Oral: Lysteda: 1.3 g three times daily for up to 5 days during monthly menstruation.  Cyklokapron [Canadian product]: 1 to 1.5 g three to four times daily for several days during menstruation.

Tooth extraction in patients with hemostatic defects (eg, hemophilia, von Willebrand disease, other factor deficiencies associated with bleeding) (adjunctive therapy):

IV: 10 mg/kg using actual body weight (usual dose range: 500 mg to 1 g) administered ~2 hours before procedure at a rate not to exceed 100 mg/minute (generally over 10 to 20 minutes), then 10 mg/kg 3 to 4 times daily for 2 to 8 days. 

Oral: 25 mg/kg (usual dose range: 1 to 1.5 g) given 2 hours prior to procedure, then 25 mg/kg (usual dose range: 1 to 1.5 g) 3 to 4 times daily for up to 7 to 10 days

How to Take: May be administered by direct IV injection at a maximum rate of 100 mg/minute as faster rates may cause hypotension.  Oral formulations can be administered without regard to meals. Swallow tablet whole; do not break, chew, or crush. Consider for use in women who decline or should not use hormonal therapy. Start once heavy menstrual bleeding has begun.

Abdominal pain, headache, back pain, musculoskeletal pain, nasal signs/symptoms

Note this is not a complete list of side effects, only the most common

1. What do I do if side effects are intolerable?
   If side effects are causing a lot of distress speak to your physician as soon as possible to discuss options.