Sovaldi (Sofosbuvir) 400mg

Sofosbuvir, Sovaldi
Description: Antihepaciviral, Polymerase Inhibitor (Anti-HCV); NS5B RNA Polymerase Inhibitor

“ALERT: US Boxed Warning

Hepatitis B virus reactivation:
Test all patients for evidence of current or prior hepatitis B virus (HBV) infection before initiating treatment with sofosbuvir. HBV reactivation has been reported in hepatitis C virus (HCV)/HBV co-infected patients who were undergoing or had completed treatment with HCV direct acting antivirals and were not receiving HBV antiviral therapy. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Monitor HCV/HBV co-infected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated.”

CSA NA – FDA Approved – REMS (N) – Can Ship

Sofosbuvir, Sovaldi Sofosbuvir, a direct-acting antiviral agent against the hepatitis C virus.  It is a prodrug converted via intracellular metabolism to its pharmacologically active form GS-461203. It inhibits HCV NS5B RNA-dependent RNA polymerase, essential for viral replication, and acts as a chain terminator.

Chronic hepatitis C

Before starting Sofosbuvir, Sovaldi make sure your physician is aware of any allergies or medications you currently take, if you have diabetes, hepatitis B, are pregnant, or breastfeeding.

400mg once daily in combination with other agents that vary with virus genotype

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day with or without food unless otherwise directed, store at room temperature.

You Need to Avoid:  Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber.

Fatigue, headache, insomnia, chills, irritability, pruritus, skin rash, nausea, decreased appetite, diarrhea, anemia, neutropenia, asthenia, myalgia, flu-like symptoms, fever

Note this is not a complete list of side effects, only the most common

1. What do I do if side effects are intolerable?
   If side effects are causing a lot of distress speak to your physician as soon as possible to discuss options.
2. Do I have to take this medication every day?
   Do not stop taking this medication, it is very important because the amount of virus in your blood may increase if the medicine is stopped even for a short time. The virus may develop resistance to this medication and become harder to treat.