Periostat (Doxycycline Hyclate) 20mg

Antibiotic, Tetracycline Derivative

CSA NA – FDA Approved – REMS (N) – Can Ship

Doxycycline inhibits protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane.  Doxycycline also inhibits matrix metalloproteinases (MMP) activity which is elevated after a tendon tear/rupture.  Doxycycline has been shown to accelerate tendon repair and improve the biomechanical properties of tendon, especially when paired with surgical management.

Officially indicated as an antibiotic for various bacterial infections.  It is sometimes used off-label for post tendon repair surgery.

Can cause esophagitis and ulcerations

Discontinue use in patients who experience a hypersensitivity syndrome, renal impairment, intracranial hypertension

Can cause photosensitivity and tissue hyperpigmentation

Post Tendon Repair Surgery

Oral: Take as directed by medical doctor; never exceed the maximum recommended daily dose.

Pros

Affordable

Well tolerated

How Do You Use Doxycycline:  Take doxycycline with food to reduce gastrointestinal symptoms.  Take with a full glass of water and do not lie down for at least 30 minutes after taking to reduce the risk of esophageal irritation and ulceration.

Is Doxycycline Safe to Use During Pregnancy:  Doxycycline is unlikely to cause any significant teratogenic risk, but the available date is insufficient to say that there is no risk.   However, tetracyclines as a class should generally be considered a second-line antibiotic in pregnant women and their use should be avoided.

Well tolerated, most side effects are transient and mild to moderate in nature.  The most common side effects include:

1-10%

Cardiovascular: Hypertension (3%)

Central nervous system: Anxiety (2%), pain (2%)

Endocrine & Metabolic: Increased lactate dehydrogenase (2%), increased serum glucose (1%)

Gastrointestinal: Diarrhea (5%), upper abdominal pain (2%), abdominal distention (1%), abdominal pain (1%), xerostomia (1%)

Hepatic: Increased serum aspartate aminotransferase (2%)

Infection: Fungal infection (2%), influenza (2%)

Neuromuscular & skeletal: Back pain (1%)

Respiratory: Nasopharyngitis (5%), sinusitis (3%), nasal congestion (2%), sinus headache (1%)