Midodrine 5mg

Midodrine, Amatine
Description: Alpha1 Agonist

“ALERT: US Boxed Warning

Appropriate use:
Because midodrine can cause marked elevation of supine blood pressure, it should be used in patients whose lives are considerably impaired despite standard clinical care. The indication for use of midodrine in the treatment of symptomatic orthostatic hypotension is based primarily on a change in a surrogate marker of effectiveness, an increase in systolic blood pressure measured 1 minute after standing, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of midodrine, principally improved ability to carry out activities of daily living, have not been verified.”

CSA NA – FDA Approved – REMS (N) – Can Ship

Midodrine, Amatine gets converted to an active metabolite, desglymidodrine, which is an alpha1-agonist. This agent increases arteriolar and venous tone resulting in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension.

Hypotension, symptomatic orthostatic

Before starting Midodrine, Amatine make sure your physician is aware of any allergies or medications you currently take, if you have diabetes, hepatic impairment, renal impairment, visual problems, pheochromocytoma, thyrotoxicosis, narrow angle glaucoma, are pregnant, or breastfeeding. Midodrine, Amatine use has been associated with rare but serious adverse events such as bradycardia and supine hypertension.

Oral: 2.5 – 10mg 3 times daily during daytime hours when patient is upright

How to Take: Doses may be given in approximately 3- to 4-hour intervals (e.g. shortly before or upon rising in the morning, at midday, in the late afternoon not later than 6 PM).

You Need to Avoid: Avoid administering <4 hours before bedtime to minimize risk of supine hypertension 

Supine hypertension, paresthesia, piloerection, pruritis, dysuria, urinary retention, urinary urgency, polyuria

Note this is not a complete list of side effects, only the most common

1. What do I do if side effects are intolerable?
   If side effects are causing a lot of distress speak to your physician as soon as possible to discuss options.