Epipen (Epinephrine) Injection JR 0.15mg

Alpha/Beta Agonist

CSA NA – FDA Approved – REMS (N) – Can Ship

Stimulates alpha-, beta1-, and beta2-adrenergic receptors resulting in relaxation of smooth muscle of the bronchial tree, cardiac stimulation (increasing myocardial oxygen consumption), and dilation of skeletal muscle vasculature; small doses can cause vasodilation via beta2-vascular receptors; large doses may produce constriction of skeletal and vascular smooth muscle

Hypersensitivity reaction, shock/hypotension (may also be used for conditions not listed)

Before starting Epinephrine, Epipen make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, diabetes, hypovolemia, Parkinson disease, pheochromocytoma, thyroid disease, or are pregnant or breastfeeding.  Use has been associated with cardiac effects (precipitate angina symptoms), pulmonary edema, decreased urine output, but this should not deter use in an emergency.

Anaphylaxis –IM: 0.2 to 0.5 mg or 0.01 mg/kg (maximum dose: 0.5 mg) 

Shock/hypovolemia dosing in practice does not necessarily match manufacturer suggested dosages

How to Take: IM administration in the anterolateral aspect of the middle third of the thigh is preferred in the setting of.  Administer through clothing if necessary. Although the manufacturers of auto-injectors recommend varying lengths of time for holding the device in the thigh (range: 2 to 10 seconds), longer times have occasionally resulted in injury. For all devices, the needle should remain in the thigh for the least amount of time as possible. With nearly every device, the full dose is delivered within 3 seconds. For EpiPen, holding the device against the leg followed by removing the cap and then compressing has been described for easier administration.

You Need to Avoid: Never reinsert needles.  Do not administer repeated injections at the same site. Do not inject into the buttocks or into digits, hands, or feet.

Angina pectoris, cardiac arrhythmia, cardiomyopathy (stress), cerebrovascular accident, chest pain, hypertension, increased cardiac work, ischemic heart disease, limb ischemia, localized blanching, myocardial infarction, palpitations, peripheral vasoconstriction, supraventricular tachycardia, tachyarrhythmia, tachycardia, vasoconstriction, ventricular arrhythmia, ventricular ectopy, ventricular fibrillation , anxiety, apprehension, cerebral hemorrhage, disorientation, dizziness, drowsiness, exacerbation of Parkinson disease, headache, memory impairment, panic, paresthesia, psychomotor agitation, restlessness, tingling sensation, diaphoresis, gangrene of skin or other tissue (at injection site), pallor, piloerection, hyperglycemia, hypoglycemia, hypokalemia, insulin resistance, lactic acidosis, nausea, vomiting, tissue necrosis at injection site, asthenia, tremor, renal insufficiency, dyspnea, pulmonary edema, rales 

Frequency of adverse reactions have not been established

1. What do I do if I accidentally inject in the wrong location?
   Accidental injection into digits, hands, or feet may result in local reactions including injection-site pallor, coldness, and hypoesthesia or injury resulting in bruising, bleeding, discoloration, erythema, or skeletal injury. Patient should seek immediate medical attention if this occurs.
2. What do I do after using epinephrine?
   Seek immediate medical attention, epinephrine does not last very long, so even if your symptoms are completely resolved at first, you need to get to a hospital as soon as possible as it will wear off within 20 minutes requiring further intervention.