Cortiment (Budesonide) 9mg

Budesonide (Enteric Coated Multimatrix Tablet), Cortiment/Uceris
Description: Corticosteroid 

CSA NA – FDA Approved – REMS (N) – Can Ship

Budesonide, Cortiment/Uceris is a synthetic glucocorticoid that acts within the gastrointestinal tract and only has a weak systemic effect.  The exact mechanism of action of Budesonide, Cortiment/Uceris is not known but is believed to be due to its ability to supress inflammatory mediators and the body’s immunological response to inflammation.  Budesonide, Cortiment/Uceris is formulated as a multi-matrix enteric coated tablet that dissolves at a pH>7, delivering Budesonide/Uceris, Cortiment to the entire colon.

Officially indicated for use in Crohn disease (mild to moderate).

Can cause hypercortisolism or suppression of the hypothalamic-pituitary-adrenal (HPA) axis, particularly in young children or if receiving high doses for prolonged periods. 

Increased risk of secondary infections due to immunosuppression associated with prolonged use of corticosteroids

Can cause development of Kaposi sarcoma, myopathy, and psychiatric disturbances

Use with caution in patients with heart failure, hypertension, diabetes, gastrointestinal disease, ocular disease, myasthenia gravis, osteoporosis, seizures disorders, hepatic and renal impairment

Crohn disease (mild to moderate)

Oral: Take 9mg once daily in the morning for up to 8 weeks; recurring episodes may be treated with a repeat 8-week course of treatment.

*Following treatment of the active disease, treatment can be continued at a daily dose of 6mg for up to 3 months.  If symptom control is maintained for 3 months, tapering of the dosage to complete cessation is recommended.

How to Take Budesonide (Enteric Coated Multimatrix Tablet), Cortiment/Uceris:  Swallow the tablet whole; do not crush, chew, or break the tablet.  It is best to take Budesonide, Cortiment/Uceris in the morning without regard to meals.

What is the Difference Between Budesonide (Enteric Coated Multimatrix Tablet), Cortiment/Uceris:  Entocort is an enteric coated capsule that has a delayed/controlled ileal release of Budesonide.  Studies have shown that Entocort is continually released during passage through the small intestine and ascending colon with the majority of absorption taking place in the ileum and ascending colon.  Uceris is formulated as an extended release 24-hour tablet which results in its time to reach peak concentration delayed compared to Entocort.

The most common side effects include:

>10%

Central Nervous System: Headache (15% to 21%)

Dermatologic: Acne vulgaris (15%)

Endocrine & Metabolic: Decreased cortisol (foam 17%; tablets 2% to 4%), bruise (15%), moon face (11%)

Gastrointestinal: Nausea (2% to 11%)

Respiratory: Respiratory tract infection (11%)