Cantharone (Cantharidin) Topical

Vesicant; Acantholytic Agent

CSA NA – Not FDA Approved – REMS (N) – Cannot Ship To US

Cantharidin, Cantharone causes blistering by breaking down the structural proteins that hold keratinocytes together.  This is thought to result in the exfoliation of the wart. When applied properly and at the right concentration it does not cause scarring as its effects do not go beyond the epidermal cells and the basal layer remains intact with minimal effect on the corneum.

Cantharidin, Cantharone is officially indicated for the removal of warts, molluscum contagiosum and periungal warts.  It is designed for application by a physician.  (May also be used for conditions not listed)

Before starting Cantharidin, Cantharone make sure your physician is aware of any allergies or medications you currently take, if you have diabetes, a condition affecting peripheral circulation, are pregnant or breastfeeding

Apply sparingly using a pointed wooden stick enough to go 1-3mm beyond the border of the wart, let dry completely then cover using a non-porous tape.  May need to repeat dose three or more times for large warts.

How to Take: 24 hours after application you may bathe and replace tape with a normal bandaid.  1-2 weeks after treatment a follow up with the physician will occur where debridement will occur, and the lesion will be assessed to see if another treatment is required.

You Need to Avoid: Do not use near eyes, mucous membranes, on ano-genital, intertriginous, or axilla areas.  Do not apply more than once a week or apply to already inflamed or irritated skin. Do not treat large areas or multiple lesions until establishing sensitivity of the patient.

Superficial annular warts may develop in a small percentage of patients as is a risk with all chemical and cryogenic procedures.  They generally present little problem if they do occur as they are superficial.  One case of chemical lymphangitis and one extreme case of painful blistering has occurred after treatment of multiple axillary lesions.  

1. What do I do if the lesion is very painful?
   If severe pain occurs after application, remove the tape and soak in cool water for 10-15 minutes until relief is achieved.  If soreness persists puncture the blister using sterile technique, apply antiseptic then cover with non-porous tape.