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Trihexyphenidyl 2mg

Description Of Product

Description: Anti-Parkinson Agent, AnticholinergicAnticholinergic Agent

CSA NA – FDA Approved – REMS (N) – Can Ship

How Does It Work

Trihexyphenidyl has a direct inhibitory effect on the parasympathetic nervous system. It also has a relaxing effect on smooth musculature via both direct action on the muscle itself and indirectly through parasympathetic nervous system.

Indications For Use

Drug-induced extrapyramidal symptoms (treatment); Parkinsonism


Before starting Trihexyphenidyl make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, a GI obstruction, glaucoma, hepatic impairment, prostatic hyperplasia/urinary stricture, have cognitive impairment, a psychiatric disorder, renal impairment, are pregnant, or breastfeeding. Trihexyphenidyl use has been associated with rare but potentially serious adverse events such as anhidrosis/hyperthermia, anticholinergic effects, CNS depression, and precipitation of narrow angle glaucoma.

Usual Dosing

Oral: Initial: 1 mg/day; increase as necessary to usual range: 5 to 15 mg/day in 3 to 4 divided doses.

Pharmacist Tips On Using

How to Take: May be administered before or after meals (if excessive dry mouth develops, consider administering before meals unless it causes nausea; postencephalitic patients who are prone to excessive salivation may prefer to take after meals); tolerated best if given in 3 daily doses and with food. High doses (>10 mg/day) may be divided into 4 doses (at each meal and at bedtime). May be taken before or after meals; tolerated best if given with food.

You Need to Avoid:  Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber. Prophylactic use is generally not recommended to prevent antipsychotic-associated extrapyramidal symptoms Have prescriber reduce dosage gradually if needed as dose reduction or discontinuation of trihexyphenidyl has been associated with neuroleptic malignant syndrome (NMS), exacerbation of Parkinsonism, and withdrawal symptoms including tension, irritability, perspiration, palpitations, headache, insomnia, abdominal distress, anorexia, faint or choking feelings, nausea, and photophobia.

Side Effects

Tachycardia, agitation, confusion, delusions, dizziness, drowsiness, euphoria, hallucination, headache, nervousness, paranoia, psychiatric disturbance, skin rash, constipation, intestinal obstruction, nausea, parotitis, toxic megacolon, vomiting, xerostomia, urinary retention, weakness, blurred vision, glaucoma, increased intraocular pressure, mydriasis

Note the frequency of side effects has not been determined in clinical trials

Frequently Asked Questions

  1. What do I do if side effects are intolerable?
    If side effects are causing a lot of distress speak to your physician as soon as possible to discuss options.
  2. What is tardive dyskinesia?
    Tardive dyskinesia is a movement disorder that is sometimes irreversible and involves involuntary movements which can impair daily function.  It generally occurs with long term use of dopamine blocking agents.  This mechanism can be compared to Parkinson’s disease due to both involving reduced dopamine resulting in involuntary movement.
  3. What is Neuroleptic Malignant Syndrome?
    NMS is a rare but serious reaction from significant blockade of dopamine which can occur from antipsychotic medications or from being on high dosages of levodopa (dopamine analogue) and stopping suddenly.  Presents initially as muscle cramps, tremors, fever, unstable blood pressure, and sudden changes in mental status.  As it progresses over 8-40 hours it can lead to complications of rhabdomyolysis, hyperkalemia, kidney failure, or seizures.  Seek medical attention immediately if this reaction is suspected.

Disclaimer: All information contained in and provided by UBACARE Your Intelligent Health Company is provided for educational purposes only. This information should not be used for diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgement or guide individual patient care in any manner.

The User is hereby notified that the information contained herein may not meet the user’s needs. The User is advised that, although the information is derived from medical research and literature, we cannot guarantee either its correctness, comprehensiveness or currency.

UBACARE Your Intelligent Health Company nor any of its affiliated parties shall be liable for any damage resulting in whole or part from any User’s use of or reliance upon the information contained within.


All orders received prior to 3:00pm PST on business days will ship the following day; peak season and holiday shipping days may require an additional 24 hours. UBACARE Pharmacy will make every effort to ship each order as quickly as possible. Orders received over the weekend will ship the following Monday as our shipping department is closed Saturday and Sunday.

We offer shipping via Canada Post within Canada.
We offer shipping via USPS and UPS within the continental United States and worldwide. Expedited shipping options are available at checkout if you want to receive your order sooner.

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UBACARE stands behind the quality of our exclusive line products by offering a 100 percent money-back guarantee to ensure customer satisfaction. To ensure the best quality, all UBACARE products are held to the strict guidelines to achieve both FDA and Health Canada Approval. UBACARE recognizes the outside agencies such as the FDA cannot control what manufacturers in other countries do and that no amount of FDA inspection can ensure a reliable supply of vital medical products. As a result, UBACARE has elected dispense primarily Canadian made generics drugs to minimize risk of contaminated products.

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Our team of pharmacists and technicians will work with you and your doctor to find therapeutic alternatives and other options to help you save.

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