Naproxen 500mg

Analgesic, Nonsteroidal Anti-inflammatory Drug (NSAID)

“Special Alerts

NSAID COVID-19 Safety Alert Updated April 2020

The FDA is aware of news reports stating that the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, could worsen coronavirus disease (COVID-19). The FDA is not aware of scientific evidence connecting the use of NSAIDs with worsening COVID-19 symptoms. The NIH recommends there should be no difference in the use of antipyretic strategies between patients with or without COVID-19.

Further information may be found at https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19 and https://covid19treatmentguidelines.nih.gov/concomitant-medications/.

ALERT: US Boxed Warning

Serious cardiovascular thrombotic events:

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction (MI), and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.

Naproxen is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.

Serious gastrointestinal bleeding, ulceration, and perforation:

NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events”

CSA NA – FDA Approved – REMS (N) – Can Ship

Naproxen/Aleve/Anaprox/Naprosyn reversibly inhibits cyclooxygenase 1 and 2 (COX 1 and 2) which decreases prostaglandin production (inflammatory mediators).  Has anti-inflammatory, analgesic, and antipyretic properties (fever reducing).

Naproxen/Aleve/Anaprox/Naprosyn is officially indicated for ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, acute flare of gout, or mild to moderate pain.  May also be prescribed off-label for migraine. (may be used for conditions not listed)

Before starting Naproxen/Aleve/Anaprox/Naprosyn make sure your physician is aware of any allergies or medications you currently take, if you have asthma, have had bariatric surgery, a history of ulcer, a bleeding disorder, drink alcohol regularly,  liver disease, kidney disease, are pregnant or breastfeeding

Note that all NSAIDs can increase risk of heart attack and stroke, as well as can cause gastrointestinal inflammation, ulceration, and bleeding.  Caution should be used in the elderly, those with cardiovascular disease and a history of gastrointestinal ulceration or bleeding.

200-750mg one to three times daily based on dosage and condition it is being used for

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature, take with food, milk or antacids to reduce adverse gastrointestinal effects, swallow whole unless otherwise directed

You Need to Avoid: Regular alcohol consumption can increase the risk of an intestinal bleed.  Do not mix with ibuprofen, ASA or other over the counter NSAIDs due to increased risk of adverse effects.

Dyspepsia (indigestion), nausea, vomiting, abdominal pain, heartburn, tinnitus (ringing in ears), fluid retention, ecchymosis (bruising), constipation, diarrhea

Note this is not a complete list of side effects, only common ones