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Moxifloxacin 400mg

Description Of Product

Antibiotic; Respiratory Fluoroquinolone

“ALERT: US Boxed Warning

Serious adverse reactions:

Fluoroquinolones have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together, including tendinitis and tendon rupture, peripheral neuropathy, and CNS effects. Discontinue moxifloxacin immediately and avoid the use of fluoroquinolones in patients who experience any of these serious adverse reactions. Because fluoroquinolones have been associated with serious adverse reactions, reserve moxifloxacin for use in patients who have no alternative treatment options for the following indications: acute bacterial sinusitis and acute bacterial exacerbation of chronic bronchitis.

Myasthenia gravis:

Fluoroquinolones may exacerbate muscle weakness in persons with myasthenia gravis. Avoid moxifloxacin in patients with known history of myasthenia gravis.”

CSA NA – FDA Approved – REMS (N) – Can Ship

How Does It Work

Inhibits DNA gyrase and topoisomerase IV in susceptible bacteria which are important in protein synthesis.  Blocking these inhibits relaxation of supercoiled DNA so it cannot be used for protein synthesis and promotes the breakage of double stranded DNA eventually causing cell death.  Humans do not have DNA gyrase which makes it an ideal target for antibiotics.

Indications For Use

Moxifloxacin is used on or off label for various infections depending on your common local bacterial strains for various infections and based on local resistance patterns.  Not all antibiotics work for all infections and efficacy can vary from area to area and vary with time.  It is common in North America for various respiratory infection hence the classification of respiratory fluoroquinolone.  


Before starting Moxifloxacin make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, kidney disease, liver disease, diabetes, rheumatoid arthritis, myasthenia gravis, or if you are pregnant, or breastfeeding.

Usual Dosing

400mg once a day

Pharmacist Tips On Using

How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, with or without food, store at room temperature

You Need to Avoid: Avoid use of antacids, multivitamins or any other sources of magnesium, aluminum, iron, or zinc.  If they are required, then take ciprofloxacin 4 hours before or 8 hours after these products as they will decrease absorption.

Side Effects

Ciprofloxacin is generally very well tolerated except in children and should be avoided in them due to risk of musculoskeletal effects unless no other options exist.  Rates of side effects in adults are quite low (under 10% risk for all) however their use needs to be limited to rare but serious irreversible side effects that may occur. 

Moxifloxacin can cause QT prolongation which can result in severe cardiac arrythmia, increased risk of aortic aneurism/dissection, irreversible tendonitis, tendon rupture, peripheral neuropathy, psychiatric symptoms (delirium, agitation, nervousness, hallucinations, paranoia) and central nervous system effects such as seizure and increased intracranial pressure.  It is also broad spectrum (kills many kinds of bacteria) which means it can increase risk of opportunistic superinfection such as C. difficile associated diarrhea.   It is important to note that these reactions are all very rare but due to their severity caution in prescribing is recommended.  

Frequently Asked Questions

  1. Why would my physician prescribe a medication with such serious side effects?
    Bacterial resistance is becoming more of an issue and not all antibiotics work for all bacteria.  Certain antibiotics concentrate in different parts of the body which can also affect which ones work in which situations.  Your physician takes the most recent clinical guidelines and follows local resistance patterns to make evidence-based decisions that are reviewed and agreed upon by the medical community as to what agents should be used in which types of infections.  Your current medications, your allergies, age, cost of medication, side effects you experience from various antibiotics and many other factors will further complicate or limit which medications are appropriate.  This decision was not made lightly, however if you are concerned, ask your physician to clarify why they made their choice of antibiotic and they can let you know why this was the best option for this scenario.
  2. What do I do if side effects are intolerable?
    If side effects are causing a lot of distress speak to your physician as soon as possible to discuss options. 

Disclaimer: All information contained in and provided by UBACARE Your Intelligent Health Company is provided for educational purposes only. This information should not be used for diagnosis or treatment of any health problem or disease. This information is not intended to replace clinical judgement or guide individual patient care in any manner.

The User is hereby notified that the information contained herein may not meet the user’s needs. The User is advised that, although the information is derived from medical research and literature, we cannot guarantee either its correctness, comprehensiveness or currency.

UBACARE Your Intelligent Health Company nor any of its affiliated parties shall be liable for any damage resulting in whole or part from any User’s use of or reliance upon the information contained within.


All orders received prior to 3:00pm PST on business days will ship the following day; peak season and holiday shipping days may require an additional 24 hours. UBACARE Pharmacy will make every effort to ship each order as quickly as possible. Orders received over the weekend will ship the following Monday as our shipping department is closed Saturday and Sunday.

We offer shipping via Canada Post within Canada.
We offer shipping via USPS and UPS within the continental United States and worldwide. Expedited shipping options are available at checkout if you want to receive your order sooner.

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UBACARE is committed to providing transparency for all its products sold online. We will share with you details such as production country, supplier names and approval status so it is easier for our customers to make more informed choices when shopping with us.

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UBACARE stands behind the quality of our exclusive line products by offering a 100 percent money-back guarantee to ensure customer satisfaction. To ensure the best quality, all UBACARE products are held to the strict guidelines to achieve both FDA and Health Canada Approval. UBACARE recognizes the outside agencies such as the FDA cannot control what manufacturers in other countries do and that no amount of FDA inspection can ensure a reliable supply of vital medical products. As a result, UBACARE has elected dispense primarily Canadian made generics drugs to minimize risk of contaminated products.

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Our team of pharmacists and technicians will work with you and your doctor to find therapeutic alternatives and other options to help you save.

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