Entecavir 0.5mg

Antihepadnaviral, Reverse Transcriptase Inhibitor, Nucleoside (Anti-HBV)

“Alert: Black Box Warning

Severe Acute Exacerbations of Hepatitis B
Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued antihepatitis B therapy, including Entecavir, Baraclud . Closely monitor hepatic function with clinical and laboratory follow-up for at least several months in patients who discontinue antihepatitis B therapy. 

HIV and Chronic Hepatitis B Virus Coinfection
Limited clinical experience suggests there is a potential for the development of resistance to HIV nucleoside reverse transcriptase inhibitors if Entecavir, Baraclude is used to treat chronic hepatitis B virus (HBV) infection in patients with HIV infection not being treated. Therapy with Entecavir, Baraclude is not recommended for HIV/HBV coinfected patients who are not also receiving antiretroviral therapy.

Lactic Acidosis and Hepatomegaly
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogue inhibitors alone or in combination with antiretrovirals.”

CSA NA – FDA Approved – REMS (N) – Can Ship 

Entecavir, Baraclude is phosphorylated to guanosine triphosphate which competes with natural substrates to effectively inhibit hepatitis B viral polymerase; enzyme inhibition blocks reverse transcriptase activity thereby reducing viral DNA synthesis.

Chronic Hepatitis B

Before starting Entecavir, Baraclude make sure your physician is aware of any allergies or medications you currently take.  Lactic acidosis and severe hepatomegaly with steatosis have been reported when using nucleoside analogue inhibitors such as Entecavir, Baraclude.  Entecavir, Baraclude should be used with caution in patients with renal and/or hepatic impairment.

Oral: Take 0.5mg to 1mg once daily.

How to Take: Take on an empty stomach, 2 hours before or after a meal.  Do not dilute or mix oral solution with water or other beverages; use calibrated oral dosing syringe. Oral solution and tablet are bioequivalent on a mg-to-mg basis.

Elevated liver enzymes, headache, fatigue, skin rash, glycosuria, hyperglycemia, abdominal pain, diarrhea, unpleasant taste, dyspepsia, hematuria.

Note this is not a complete list of side effects for Entecavir, Baraclude only common ones.

1. Do I have to take this medication every day?
   Do not stop taking this medication, it is very important because the amount of virus in your blood may increase if the medicine is stopped even for a short time. The virus may develop resistance to this medication and become harder to treat.
2. What do I do if side effects are intolerable?
   If side effects are causing a lot of distress speak to your physician as soon as possible to discuss options.